AirHint found the following cheapest one-way flights from Chicago (ORD) to Sao Paulo (GRU) in April 2026 (see full year).
One-Way flights
| 13 Apr | Frontier Airlines | ||
| 12 Apr | Spirit Airlines | ||
| 05 Apr | Spirit Airlines | ||
| 22 Apr | Frontier Airlines | ||
| 01 Apr | Arajet | ||
| 25 Apr | Frontier Airlines | ||
| 17 Apr | Copa | ||
| 18 Apr | Copa | ||
| 19 Apr | Copa | ||
| 09 Apr | Copa |
Also check the deals for return flights from Chicago to Sao Paulo in April.
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