AirHint found the following cheapest one-way flights from Melbourne (MEL) to Santiago (SCL) in December 2025 (see full year).

One-Way flights

24 Dec	LATAM Airlines Group	direct
29 Dec	Jetstar
29 Dec	LATAM Airlines Group	direct
09 Dec	Jetstar
02 Dec	Qatar Airways
04 Dec	Qantas	direct
01 Dec	Qantas	direct
17 Dec	American Airlines
02 Dec	Qantas	direct
26 Dec	Jetstar

Also check the deals for return flights from Melbourne to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santiago

Cheap car rent in Santiago

Cheapest one-way flights from Melbourne to Santiago in December from 1062€

One-Way flights