AirHint found the following cheapest one-way flights from Melbourne (MEL) to Santiago (SCL) in December 2025 (see full year).

One-Way flights

25 Dec	LATAM Airlines Group	direct
30 Dec	Jetstar
30 Dec	LATAM Airlines Group	direct
28 Dec	LATAM Airlines Group	direct
10 Dec	Cathay Pacific
04 Dec	Qantas	direct
01 Dec	Qantas	direct
07 Dec	Qantas
06 Dec	Qantas
23 Dec	American Airlines

Also check the deals for return flights from Melbourne to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Melbourne to Santiago in December from 1062€

One-Way flights