Cheapest one-way flights from Chicago to Brussels in December from 297€

AirHint found the following cheapest one-way flights from Chicago (MDW) to Brussels (BRU) in December 2025 (see full year).

One-Way flights

09 Dec Frontier Airlines
11 Dec Frontier Airlines
13 Dec Frontier Airlines
05 Dec Frontier Airlines
24 Dec Frontier Airlines
23 Dec Frontier Airlines
25 Dec Frontier Airlines
12 Dec Frontier Airlines
18 Dec Frontier Airlines
01 Dec KLM

Also check the deals for return flights from Chicago to Brussels in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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