Cheapest one-way flights from Madrid to Santa Cruz in April from 320€

Best time to book flights for Madrid (MAD) to Santa Cruz (VVI) flights at AirHint

AirHint found the following cheapest one-way flights from Madrid (MAD) to Santa Cruz (VVI) in April 2025 (see full year).

One-Way flights

02 Apr Boliviana de Aviacion direct
20 Apr Air Europa direct
23 Apr Air Europa direct
11 Apr Iberia direct
25 Apr Iberia direct
24 Apr LATAM Airlines Group
10 Apr LATAM Airlines Group
19 Apr LATAM Airlines Group

Also check the deals for return flights from Madrid to Santa Cruz in April.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santa Cruz

Cheap car rent in Santa Cruz