AirHint found the following cheapest one-way flights from Madrid (MAD) to Santa Cruz (VVI) in November 2025 (see full year).

One-Way flights

12 Nov	Azul Airlines
13 Nov	Avianca
16 Nov	Avianca
10 Nov	Avianca
07 Nov	Boliviana de Aviacion	direct
05 Nov	Boliviana de Aviacion	direct
21 Nov	Iberia	direct
16 Nov	Iberia	direct
19 Nov	Iberia	direct
08 Nov	Avianca

Also check the deals for return flights from Madrid to Santa Cruz in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Madrid to Santa Cruz in November from 363€

One-Way flights