AirHint found the following cheapest one-way flights from Lyon (LYS) to Prague (PRG) in October 2025 (see full year).

One-Way flights

31 Oct	Volotea	direct
29 Oct	Volotea	direct
12 Oct	easyJet	direct
15 Oct	easyJet	direct
05 Oct	easyJet	direct
20 Oct	Volotea	direct
08 Oct	easyJet	direct
26 Oct	Volotea	direct
19 Oct	easyJet	direct
30 Oct	easyJet	direct

Also check the deals for return flights from Lyon to Prague in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Lyon to Prague in October from 29€

One-Way flights