Cheapest one-way flights from Houston to Santiago in December from 273€

AirHint found the following cheapest one-way flights from Houston (IAH) to Santiago (SCL) in December 2025 (see full year).

One-Way flights

14 Dec Spirit Airlines
13 Dec Frontier Airlines
25 Dec Frontier Airlines
24 Dec Frontier Airlines
25 Dec United direct
13 Dec United direct
14 Dec United direct
21 Dec Avianca
21 Dec United direct
24 Dec United direct

Also check the deals for return flights from Houston to Santiago in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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