AirHint found the following cheapest one-way flights from Sao Paulo (GRU) to Santiago (SCL) in December 2025 (see full year).

One-Way flights

13 Dec	Sky Airline	direct
05 Dec	Sky Airline	direct
12 Dec	Sky Airline	direct
14 Dec	Sky Airline	direct
10 Dec	Sky Airline	direct
19 Dec	Sky Airline	direct
31 Dec	Sky Airline	direct
16 Dec	Sky Airline	direct
25 Dec	Sky Airline	direct
24 Dec	Sky Airline	direct

Also check the deals for return flights from Sao Paulo to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santiago

Cheap car rent in Santiago

Cheapest one-way flights from Sao Paulo to Santiago in December from 63€

One-Way flights