AirHint found the following cheapest one-way flights from Cuzco (CUZ) to Santiago (SCL) in September 2025 (see full year).

One-Way flights

30 Sep	Sky Airline
29 Sep	JetSmart
28 Sep	JetSmart
26 Sep	JetSmart
23 Sep	LATAM Airlines Group
30 Sep	LATAM Airlines Group	direct
29 Sep	LATAM Airlines Group	direct
23 Sep	LATAM Airlines Group	direct
28 Sep	LATAM Airlines Group	direct
26 Sep	LATAM Airlines Group	direct

Also check the deals for return flights from Cuzco to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Cuzco to Santiago in September from 123€

One-Way flights