Cheapest one-way flights from Rome to Prague in September from 45€

Best time to book flights for Rome (CIA) to Prague (PRG) flights at AirHint

AirHint found the following cheapest one-way flights from Rome (CIA) to Prague (PRG) in September 2025 (see full year).

One-Way flights

23 Sep Ryanair direct
04 Sep Ryanair direct
24 Sep Ryanair direct
26 Sep Ryanair direct
27 Sep Ryanair direct
28 Sep Ryanair direct
29 Sep Ryanair direct
01 Sep Ryanair direct
14 Sep Ryanair direct
15 Sep Ryanair direct

Also check the deals for return flights from Rome to Prague in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Prague

Cheap car rent in Prague